Is there any chance of problem when running multiple nodes with Let's Encrypt enabled?

I was reading https://github.com/traefik/traefik/issues/5426, and now I'm wondering, is there any chance of problem or failure, when running separate traefik instances with Let's Encrypt enabled and load balancing between them?

Hello,

it is strongly discouraged to create a cluster by sharing the acme.json file.
Because you will have concurrent access to file and concurrent challenges.

I did not say that I'm going to share that file between instances. I was thinking to bring up some completely separate instances and let each of them to get its own certificate. Would it be possible without problem?